Physical and Theoretical Chemistry

Drug Design and Drug Discovery

Potentially new medicinal entities are found through the process of drug discovery, which combines computational, experimental, translational, and clinical models. Drug development is still a drawn-out, expensive, challenging, and ineffective process with a high attrition rate of novel therapeutic discovery, despite advancements in biotechnology and understanding of biological systems. The creative process of developing novel drugs based on an understanding of a biological target is known as drug design. Designing molecules that are complementary in shape and charge to the molecular target with which they interact and bind is the most fundamental aspect of medication development. Preclinical research using cell-based and animal models, human clinical trials, and finally securing regulatory approval to market the treatment are all steps in the development and discovery of new drugs.